# Profluent-AI/OpenCRISPR

AI-generated gene editing systems

Repository: https://github.com/Profluent-AI/OpenCRISPR
Canonical: https://ross.abutalabs.com/products/opencrispr
License Family: other
Last push: 2025-09-26T19:21:36+00:00

## Health v2 (maintenance only)
Score: 44/100 (v2, computed 2026-09-03T02:20:16.233290+00:00)
- activity 44, release rhythm 35, longevity 62
- inputs: {"age_days": 869, "days_push": 341, "days_rel": null, "gap_med": null, "n_releases_24m": 0}
- flags: no_releases, no_license
- formula: round(0.45*activity + 0.35*rhythm + 0.20*longevity); archived -> min(score, 10)

## Adoption (not part of the score)
Stars 1204, forks 128 (observed 2026-08-28T04:03:59.048301+00:00)

## What it is
OpenCRISPR is a collection of AI-designed gene editing systems released by Profluent Bio, including OpenCRISPR-1, a Cas9-like protein and guide RNA generated with protein language models. The repository distributes the protein sequences and license terms rather than executable software.

## Use cases
- find an AI-designed Cas9 replacement for gene editing protocols
- download open gene editor protein sequences for research
- use a drop-in SpCas9 alternative with NGG PAM
- build base or prime editing systems with a novel nuclease
- study LLM-designed proteins for biotech applications

## When to choose
- you need a freely licensed Cas9-like editor for research or commercial development
- you want to evaluate AI-generated gene editing proteins
- you need a nuclease compatible with canonical SpCas9 guide RNAs

## When to avoid
- you expect runnable software, code, or pipelines - this is sequence data
- your jurisdiction or use case conflicts with the required license agreement
- you need a fully unrestricted open-source license without terms of use

## Facets
- artifact type: dataset
- maturity: active
- function: machine-learning, llm-training, data-generation
- domain: bioinformatics, artificial-intelligence, healthcare
- platform: cross-platform
- tags: crispr, gene-editing, protein-design, biotechnology, synthetic-biology, protein-sequences

## Member repositories
- Profluent-AI/OpenCRISPR (main) score 44

## Provenance
- Observed fields: from GitHub, fetched 2026-08-28T04:03:59.048301+00:00.
- Health v2: computed from the inputs above; adoption is never an input.
- Inferred fields (summary, facets, guidance): AI-extracted, prompt v1, taxonomy v1, on 2026-08-30T06:19:38.453940+00:00, confidence not recorded.
  - readme: https://github.com/Profluent-AI/OpenCRISPR (fetched 2026-08-28T04:03:59.048301+00:00, sha ed7a9df7cdb8)
- Data as of 2026-08-30T08:39:29.467469+00:00.