# bbuchfink/diamond

Accelerated BLAST compatible local sequence aligner.

Repository: https://github.com/bbuchfink/diamond
Canonical: https://ross.abutalabs.com/products/bbuchfink-diamond
Language: C++
License: GPL-3.0
License Family: copyleft
Topics: sequence-alignment
Last push: 2026-08-04T18:26:34+00:00

## Health v2 (maintenance only)
Score: 97/100 (v2, computed 2026-09-03T02:20:16.233290+00:00)
- activity 96, release rhythm 96, longevity 100
- inputs: {"age_days": 4194, "days_push": 29, "days_rel": 30, "gap_med": 18, "n_releases_24m": 22}
- flags: none
- formula: round(0.45*activity + 0.35*rhythm + 0.20*longevity); archived -> min(score, 10)

## Adoption (not part of the score)
Stars 1316, forks 201 (observed 2026-08-28T04:04:20.878883+00:00)

## What it is
DIAMOND is a BLAST-compatible local sequence aligner for protein and translated DNA searches, designed for high-performance analysis of large sequence data. It also supports protein sequence clustering and taxonomic classification with output in BLAST pairwise, tabular, and XML formats.

## Use cases
- align protein sequences against a reference database
- run BLAST-like searches 100x faster on big sequence data
- cluster large protein sequence datasets
- classify sequences taxonomically
- align long reads with frameshift-aware alignment
- analyze metagenomic sequencing data

## When to choose
- you need BLAST-compatible alignments but BLAST is too slow for your data volume
- you are processing large-scale sequencing or metagenomic datasets
- you need protein sequence clustering that scales across compute nodes
- you want low resource requirements that run on a desktop or laptop

## When to avoid
- you need the exact sensitivity or feature set of NCBI BLAST for small queries
- you require a graphical interface rather than a command-line tool
- your task is nucleotide-only alignment without translated searches

## Facets
- artifact type: cli-tool
- maturity: active
- function: search-engine
- domain: bioinformatics
- platform: windows, cli, cpp
- tags: blast, sequence-alignment, bioinformatics, genomics, protein-alignment, high-performance, linux, macos

## Member repositories
- bbuchfink/diamond (main) score 97

## Provenance
- Observed fields: from GitHub, fetched 2026-08-28T04:04:20.878883+00:00.
- Health v2: computed from the inputs above; adoption is never an input.
- Inferred fields (summary, facets, guidance): AI-extracted, prompt v1, taxonomy v1, on 2026-08-30T04:48:27.418654+00:00, confidence not recorded.
  - readme: https://github.com/bbuchfink/diamond (fetched 2026-08-28T04:04:20.878883+00:00, sha addcafd79f9e)
- Data as of 2026-08-30T08:39:29.467469+00:00.